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What is Reverse T3?

Dr. Linda Khoshaba

February 6, 2023

T3 is a thyroid hormone known as triiodothyronine. Reverse T3 (rT3) is the inactive form of the hormone. It is converted from T4 through the enzyme called 3-5’-deiodinase enzyme. 3-5’-deiodinase enzymes then decompose into diiothyronine. Elevation of rT3 can come from the increased conversion of T4 to rT3 or inability for rT3 to convert to diiothyronine. This can lead to signs of hypothyroidism.

How is T3 produced?

Thyroid hormones for what is reverse T3?

T3 is produced with T4 and calcitonin from the thyroid gland, located in the anterior region of the neck. About 80 percent of the thyroid gland makes T4, while the remaining 20 percent is T3. T4 is responsible for converting to T3 through the enzyme 3-5’-deiodinase enzyme, as mentioned above. 

What does Reverse T3 affect?

Thyroid hormones are responsible for many aspects of the human body. It plays an important role in metabolism, growth, and other developmental aspects. 

Since the conversation of T4 to T3 is blocked, that results in high 

This section is incomplete; should I add some more info or omit the section?

Natural Treatments for Reverse T3 

Luckily, there are natural remedies for treating Reverse T3. These foods, supplements, and lifestyle changes will allow boost 

This section too

  • Selenium
  • Idoine 
  • Zinc
  • Essential Fat
  • Liver Detoxification 
  • Glycemic foods 
  • Low Impact Exercise
    • Exercise is an essential part of life that should always be included in one’s routine. While movement and exercise are essential for circulation, the low impact may be less stressful on the body
  • Reduce Stress
    • Indicate stressors in your life and try to find ways to reduce those stressors
  • Cold therapy 


Gomes-Lima C, Wartofsky L, Burman K. Can Reverse T3 Assay Be Employed to Guide T4 vs. T4/T3 Therapy in Hypothyroidism? Front Endocrinol (Lausanne). 2019 Dec 11;10:856. doi: 10.3389/fendo.2019.00856. PMID: 31920970; PMCID: PMC6917573.

Halsall DJ, Oddy S. Clinical and laboratory aspects of 3,3',5'-triiodothyronine (reverse T3). Ann Clin Biochem. 2021 Jan;58(1):29-37. doi: 10.1177/0004563220969150. Epub 2020 Nov 4. PMID: 33040575.

Spencer CA, Takeuchi M, Kazarosyan M. Current status and performance goals for serum thyrotropin (TSH) assays. Clin Chem 1996; 42:140.

What is reverse T3?

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Dr. Linda Khoshaba is the Leading Integrative Health and Hormone Doctor in Scottsdale, Arizona. She has extensive experience working in the field as a Hormone Specialist and Natural Endocrinologist.

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AZ 85255, Suite 200
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